Occupational exposure to pesticides and central nervous system tumors: results from the CERENAT case–control study

The etiology of the central nervous system (CNS) tumors remains largely unknown. role pesticide exposure has been suggested by several epidemiological studies, but with no definitive conclusion. To analyze associations between occupational and primary CNS in adults CERENAT study. is a multicenter case–control study conducted France 2004–2006. Data about uses—in outside agriculture—were collected during detailed face-to-face interviews reviewed experts for consistency assignment. Odds ratios (ORs) 95% confidence intervals (95% CI) were estimated conditional logistic regression. A total 596 cases (273 gliomas, 218 meningiomas, 105 others) 1 192 age- sex-matched controls selected general population analyzed. Direct indirect exposures to pesticides agriculture respectively assigned 125 (7.0%) 629 (35.2%) individuals 146 (8.2%) individuals. For overall agricultural exposure, we observed increase risk all brain (OR 1.04, 0.69–1.57) slight gliomas 1.37, 0.79–2.39). Risks higher when considering more than 10 years 2.22, 0.94–5.24) significantly trebled open field 3.58, 1.20–10.70). Increases also non-agricultural exposures, especially green space workers who directly exposed 1.89, 0.82–4.39), these statistically significant those over 2.84, 1.15–6.99). These data support some previous findings regarding potential tumors, both inside agriculture.